Original article published on JACS.
Researchers at UCL and UPF could confirm that a conformational distribution across open and closed states of HIV-1 RT must exist in the NNRTI-bound enzyme and that allosteric modulation is effected via the alteration of the kinetic landscape of conformational transitions upon drug-binding.
Adapted with permission from “D. W. Wright, S. K. Sadiq, G. De Fabritiis, P. V. Coveney, Thumbs Down for HIV: Domain Level Rearrangements Do Occur in the NNRTI-Bound HIV-1 Reverse Transcriptase, J. Am. Chem. Soc., 2012, 134 (31), 12885–12888”. Copyright 2012 American Chemical Society.